Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.

نویسندگان

  • S K Hore
  • H C Tripathi
  • S K Tandan
  • D Kumar
چکیده

Possible modulation of the Brewer's yeast-induced peripheral inflammation by two central neuropeptides, bradykinin and substance P (SP), was investigated in rats. Centrally administered bradykinin significantly increased pedal oedema and pain threshold whereas, SP produced significant augmentation of oedema volume and nociception. The results of the present study indicate that central bradykinin exerts pro-inflammatory and analgesic effects whereas, central SP exerts pro-inflammatory and pro-nociceptive effects on Brewer's yeast-induced peripheral inflammation.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways.

In the vagal-sensory system, neuropeptides such as substance P and calcitonin gene-related peptide (CGRP) are synthesized nearly exclusively in small-diameter nociceptive type C-fiber neurons. By definition, these neurons are designed to respond to noxious or tissue-damaging stimuli. A common feature of visceral inflammation is the elevation in production of sensory neuropeptides. Little is kno...

متن کامل

Redox-Dependent Modulation of T-Type Ca2+ Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P

AIMS Neuropeptide substance P (SP) is produced and released by a subset of peripheral sensory neurons that respond to tissue damage (nociceptors). SP exerts excitatory effects in the central nervous system, but peripheral SP actions are still poorly understood; therefore, here, we aimed at investigating these peripheral mechanisms. RESULTS SP acutely inhibited T-type voltage-gated Ca(2+) chan...

متن کامل

Kinin receptor antagonists as potential neuroprotective agents in central nervous system injury.

Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodi...

متن کامل

Anti-inflammatory Activity of Essential Oil of Canarium Strictum Roxb

Canarium L. is used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor, heptoprotective, antioxidant, and anti diabetic properties. The present study investigeated the invivo anti-inflammatory activity of  essential oil obtained by hydrodistillation of resin of Canarium strictum Roxb. In the current study, anti-inflammatory activity of essential oil of...

متن کامل

The history of neuropeptides III.

One of the important developments during the neuroendocrine period from 1955 to 1973 was the emergence of a new, unique research area: systematic studies of the actions of peptides on the central nervous system, including psychotropic and behavioral effects. During this period, the studies were concerned primarily with substance P, bradykinin, angiotensin,ACTH,MSH, and vasopressin. Studies on s...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 40 4  شماره 

صفحات  -

تاریخ انتشار 1996